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Fully sequenced samples of complimentary DNA synthesized from single-stranded, mammalian RNA. Various gene inserts sourced from humans, mice, monkeys, and other species are available. Ideal for use in gene cloning, as gene probes, and in cDNA library creation.
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This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants.
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Tumor necrosis factor receptor superfamily member 4 (TNFRSF4) also known as CD134 and OX40 receptor OX40 is a secondary co-stimulatory immune checkpoint molecule expressed after 24 to 72 hours following activation its ligand OX40L is also not expressed on resting antigen presenting cells but is following their activation
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Shionogi CCR8 Biosimilar Antibody is a biosimilar antibody with human reactivity produced in humanized Available in 100 ug size with 7 - 14 business days lead time Ships via gel pack Store at -20 C to -80 C for 12 months in lyophilized form After reconstitution if not intended for use within a month aliquot and store at -80 C (Avoid repeated freezing and thawing) Lyophilized antibodies are shipped at ambient temperature
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DNAM-1 (DNAX accessory molecule-1) also known as CD226 platelet and T cell activation antigen 1 (PTA1) and TLiSA1 is a member of the Ig superfamily containing two Ig-like domains of the V set and is encoded by a gene on human chromosome 18q22 3 DNAM-1 is an activating receptor expressed on natural killer (NK) cells CD8 T cells and other immune cells Upon recognition of its ligands CD155 and CD112 DNAM-1 promotes NK cell mediated elimination of transformed and virus-infected cells It also has a key role in expansion and maintenance of virus-specific memory NK cells DNAM-1 is the cell surface receptor of NECTIN2 Upon ligand binding it stimulates T cell proliferation and cytokine production including that of IL2 IL5 IL10 IL13 and IFNG
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Immunoglobulin G (IgG) Fc receptors play a critical role in linking IgG antibody-mediated immune responses with cellular effector functions A high resolution map of the binding site on human IgG1 for human Fc gamma RI Fc gamma RIIA Fc gamma RIIB Fc gamma RIIIA and FcRn receptors has been determined A common set of IgG1 residues is involved in binding to all Fc gamma R Fc gamma RII and Fc gamma RIII also utilize residues outside this common set
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